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- Make sure Python is configured with large file support. “from test import largefile”.
- Bumping up the number of Zope threads via “-t” in Zope 2.6 or “zserver-threads” entry in Zope 2.7 likely won't improve performance if your app is CPU or memory bound.
- You can increase or decrease the # of connections available in a database's connection pool (via custom_zodb.py in Zope 2.6 or pool-size parameter to zodb_database stanza in Zope 2.7). Make sure you have enough connections to service the # of threads you create.